Table 1. Genotypic and allelic frequencies of rs13140012, rs6553010, and rs2119882 in the melatonin receptor type 1A gene.
| Polymorphism | Controln (%) | GDn (%) | HTn (%) | AITDn (%) | OR1 (95% CI) | OR2 (95% CI) | OR3 (95% CI) |
|---|---|---|---|---|---|---|---|
| rs6553010 | |||||||
| AA | 159 (45.3) | 162 (50.9) | 30 (36.1) | 192 (47.8) | 1 | 1 | 1 |
| AG | 149 (42.5) | 120 (31.7) | 39 (47.0) | 159 (39.7) | 0.79 (0.57~1.09) | 1.39 (0.82~2.35) | 0.83 (0.65~1.20) |
| GG | 43 (12.3) | 36 (11.3) | 14 (16.9) | 50 (12.5) | 0.82 (0.50~1.35) | 2.34 (0.24~22.7) | 0.96 (0.61~1.52) |
| AG+GG | 192 (54.8) | 156 (43.0) | 53 (63.9) | 209 (52.2) | 0.80 (0.59~1.08) | 1.46 (0.89~2.40) | 0.90 (0.68~1.20) |
| Allele | |||||||
| A | 467 (66.5) | 444 (69.8) | 99 (60.7) | 543 (67.7) | 1 | 1 | 1 |
| G | 235 (33.5) | 192 (30.2) | 67 (39.3) | 259 (32.3) | 0.86 (0.68~1.08) | 1.35 (0.95~1.90) | 0.95 (0.76~1.18) |
| rs13140012 | |||||||
| AA | 140 (39.9) | 149 (46.9) | 26 (31.3) | 175 (43.6) | 1 | 1 | 1 |
| AT | 165 (47.0) | 136 (42.8) | 46 (55.4) | 182 (45.4) | 0.77 (0.56~1.07) | 1.50 (0.88~2.55) | 0.88 (0.65~1.20) |
| TT | 46 (13.1) | 33 (10.4) | 11 (13.3) | 44 (11.0) | 0.67 (0.41~1.12) | 1.29 (0.59~1.81) | 0.73 (0.46~1.17) |
| AT+TT | 201 (60.1) | 169 (53.2) | 57 (68.7) | 216 (56.4) | 0.75 (0.55~1.02) | 1.46 (0.87~2.42) | 0.85 (0.64~1.14) |
| Allele | |||||||
| A | 445 (63.4) | 434 (68.2) | 98 (59.0) | 532 (66.3) | 1 | 1 | 1 |
| T | 257 (36.6) | 202 (31.8) | 68 (41.0) | 270 (33.7) | 0.81 (0.64~1.01) | 1.20 (0.85~1.70) | 0.87 (0.70~1.07) |
| rs2119882 | |||||||
| TT | 140 (39.9) | 153 (48.1) | 28 (33.7) | 181 (45.1) | 1 | 1 | 1 |
| CT | 166 (47.3) | 132 (41.5) | 43 (51.8) | 175 (43.6) | 0.73 (0.53~1.01) | 1.30 (0.77~2.19) | 0.82 (0.60~1.11) |
| CC | 45 (12.8) | 33 (10.4) | 12 (14.5) | 45 (11.2) | 0.67 (0.41~1.11) | 1.33 (0.63~2.84) | 0.77 (0.48~1.24) |
| CC+CT | 211 (60.1) | 165 (51.9) | 55 (66.3) | 220 (54.8) | 0.72(0.53~0.97* | 1.30 (0.79~2.76) | 0.81 (0.60~1.08) |
| Allele | |||||||
| T | 446 (63.5) | 438 (68.9) | 99 (60.7) | 537 (67.0) | 1 | 1 | 1 |
| C | 256 (36.5) | 198 (31.1) | 67 (39.3) | 265 (33.0) | 0.79(0.63~0.99* | 1.18 (0.83~1.67) | 0.86 (0.70~1.06) |
GD, Graves’ disease; HT, Hashimoto’s thyroiditis; AITD, autoimmune thyroid disease (GD + HT); control, control group. OR1, odds ratio 1, GD vs. the control; OR2, odds ratio 2, HT vs. the control; OR3, odds ratio 3, AITD vs. the control; CI, confidence interval
* p<0.05.