Fig 3. Comparison of effects of thyroid hormone on the progenitors in the megakaryocyte/erythroid lineage of wild-type and Thra1^PV/+ mice.

(A) Serum total T3 (panel a), total T4 (panel b), and TSH (panel c) were determined from wild type and Thra1^PV/+ mice (each n = 3) under the euthyoid, hypothyroid and hyperthyroid condition as described in Methods. (B) Colonies of erythroid progenitors (BFU-E, panel a, and CFU-E, panel b) and megakaryocytic progenitors (CFU-Mk, panel c) were counted from total bone marrow of euthyroid (filled bars), hypothyroid (grey bars), and hyperthyroid (open bars) mice. Values are means ± SEM (duplicates in each assay from WT mice, n = 3; Thra1^PV/+ mice, n = 3). * denotes p<0.05; ** denotes p<0.01; *** p<0.001.