Figure 1:

Multiparametric MR imaging and tissue specimen image processing. (a) Presurgical MR images are acquired and used to construct a three-dimensional (3-D) volume of the prostate and a PSM. (b) Whole-mount tissue specimens are cut in the mold and stained with hemotoxylin-eosin (H&E) for histopathologic evaluation. (c) Image registration is performed (T2-weighted MR images to DW images, MR images to digitized tissue specimen images). (d) Tissue specimen images are segmented into four tissue components. By using segmentation, the tissue component densities are estimated per MR imaging voxel and then (e) whole-density maps are computed.