Figure 15a.

Sarcoid-like lymphadenopathy in an asymptomatic 81-year-old man with metastatic melanoma treated with ipilimumab. (a) Coronal contrast-enhanced reformatted chest CT image obtained 4.9 months after the initiation of ipilimumab therapy shows new bilateral symmetric mediastinal and hilar lymphadenopathy (arrows) resembling findings of sarcoidosis. (b) Axial CT image shows bilateral irregular and nodular parenchymal opacities (arrows) with upper- and middle-lung predominance and peribronchovascular involvement. The findings fall in the spectrum of lung parenchymal manifestations of pulmonary sarcoidosis. (Figure reprinted from reference 16.)