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Rats were injected at the sciatic nerve with polymeric (poly(lactic-co-glycolic acid) [PLGA]) microspheres containing tetrodotoxin (TTX) and/or bupivacaine and/or dexamethasone. Two-compound formulations had a longer duration of effect than did single-compound ones, and microspheres containing all three compounds had an even longer duration of effect (>9 days from a single injection). Reprinted with permission from Lippincott Williams. [10] Copyright 2003.
