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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Curr Opin Toxicol. 2017 Mar 1;2:109–119. doi: 10.1016/j.cotox.2017.02.004

Figure 1.

Figure 1

Schematic illustration of the repression of the canonical AhR signaling pathway by AhRR. The ligand-activated AhR translocates into the nucleus, dimerizes with ARNT and binds on DRE sequences in the promoter region of AhR target genes, including CYP1A1 and AhRR. The increased expression of AhRR inhibits AhR activity as a result from the competition with AhR for dimerization with ARNT. Alternatively, the formation of an AhRR/ARNT complex may inhibit AhR function through binding on DRE sequences, which does not involve the competition for dimerization with ARNT.