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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Curr Opin Toxicol. 2017 Mar 1;2:109–119. doi: 10.1016/j.cotox.2017.02.004

Figure 2.

Figure 2

Schematic illustration of the interaction of AhRR with the canonical and non-canonical AhR pathways. AhRR represses the canonical AhR pathway including the induction of CYP1A1 via competitive binding with ARNT. AhRR may protect from non-canonical AhR-mediated inflammatory responses and inflammation-dependent carcinogenesis via interaction of AhRR with RelB in complex with ARNT and/or AhR. Black double arrows indicate the interaction of AhRR with ARNT and RelB with AhR. The white double arrow indicates the interaction of ARNT with RelB. Abbreviations: Protein kinase A (PKA)