Table 1.

Effects of AhRR overexpression and RNAi on cell biological endpoints and gene expression in vitro.

CELL-LINE	MANIPULATION	OUTCOME	REF #
A549 bronchoalveolar carcinoma cells	overexpression of human AhRR	diminished anchorage-dependent and -independent cell growth, reduced angiogenic potential (tube formation)	73
A549 cells	transient RNAi of AhRR	enhanced anchorage-dependent and -independent cell growth	73
BP1 mammary epithelial cells	overexpression of fish AhRR (Fundulus heteroclitus)	reduced constitutive AhR activity; reduced expression of CYP1B1	60
MCF7 breast cancer cells	overexpression of human AhRR	reduced cell proliferation; increased expression of cyclin D1; reduced expression of E2F and cathepsin D	86
MCF7 cells	overexpression of human AhRR	reduced expression of the estrogen-responsive genes pS2, cathepsin D, and complement C3	87
MCF7 cells	transient RNAi of AhRR	no effect on TCDD-induced expression of CYP1A1, CYP1B1, and TCDD- inducible poly (ADP-ribose) polymerase	125
MCF-10AT1 mammary epithelial cells	overexpression of murine AhRR	enhanced susceptibility towards UV-induced apoptosis	87
MCF-10A mammary epithelial cells	stable RNAi targeting AhRR	induced colony formation in soft agar	73
MCF-10F mammary epithelial cells	overexpression of fish AhRR (F. heteroclitus)	reduced cell proliferation	85
MCF-10F cells	lentiviral overexpression of fish AhRR (F. heteroclitus)	reduced constitutive AhR activity; reduced expression of CYP1B1	60
HC11 mammary epithelial cells	overexpression of human AhRR	reduced expression of 3-casein	126
HepG2 hepatoma cells	overexpression of human AhRR	reduced expression of the estrogen-responsive genes pS2, cathepsin D, and complement C3	87
Hs578T breast cancer cells	overexpression of fish AhRR (F. heteroclitus)	reduced constitutive AhR activity; no effect on cell proliferation	127
Hs578T cells	overexpression of fish AhRR (F. heteroclitus)	increased expression of the proto-oncogene c-myc	128