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. 2017 Sep 7;2(17):e93961. doi: 10.1172/jci.insight.93961

Figure 3. Somatic mutations in IGHV3-15 and the effect of positions involved in binding on the affinity of 1E03 hmAb.

Figure 3

(A) Frequency of amino acid substitution along the IGHV3-15 gene segment of DGP-reactive and non–DGP-reactive PCs from a representative CD patient with more than 30 sequences available for analysis. (B) The effect of single amino acid substitution on binding affinity of hmAbs 1E03 to DGP as assessed by MST (average of 3 measurements ± SD). Variants at R55-H and T113-L were tested. GL, germline; VH, heavy chain; VΚ, Κ light chain.