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. 2017 Sep 7;2(17):e93343. doi: 10.1172/jci.insight.93343

Figure 2. Tead1 deletion in adult cardiomyocytes leads to acute dilated cardiomyopathy.

Figure 2

(A) heart weight/body weight (HW/BW) ratio, (B) heart weight/tibial length (HW/TL) ratio, and (C) body weight, all after 6 weeks of the diet protocol. ***P < 0.001; data were analyzed by 1-way ANOVA with Tukey’s post hoc test. Comparisons between Tead1-icKO mice (n = 6) and TeadF/F chow diet mice (n = 4), TeadF/F TM diet mice (n = 4), Myh6-CreER TM diet mice (n = 3), or TeadF/F;Myh6-CreER chow diet mice (n = 3). No significance was present among the 4 control groups. (D) Trichrome staining of transverse and coronal section of the hearts from the TeadF/F TM diet and Tead1-icKO mouse. Scale bars: 1 mm. (E) Trichrome staining and wheat germ agglutinin (WGA, red; DAPI, blue) staining. Scale bars: 40 μm.