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. 2017 Sep 7;2(17):e93343. doi: 10.1172/jci.insight.93343

Figure 4. Tead1 is required for the phosphorylation of phospholamban (Pln).

Figure 4

(A) Phosphorylation levels of Pln on Ser16/Thr17 in control and Tead1-icKO hearts. (B) Effects of foskolin (Fsk) 25 μmol/l and isoproterenol (Iso) 5 μmol/l on pPlnSer16 protein levels in lacZ or Cre adenovirus–treated Tead1-flox neonatal CMs (NCMs). (C) Immunoblot showing the rescue of phosphorylation of Pln at Ser16 by reexpression of TEAD1 in Tead1-icKO NCMs. (D) Effects of Fsk and Iso on pPlnSer16 protein levels in control vector and TEAD1-overexpressed NCMs.