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. 2017 Sep 7;2(17):e93343. doi: 10.1172/jci.insight.93343

Figure 5. Increased SR-associated protein phosphatase 1 (PP1) activity in Tead1-icKO hearts.

Figure 5

(A) SR-associated protein phosphatase 1 (PP1) activity in control and Tead1-icKO hearts (n = 3). (B) I-1 and I-2 mRNA expression levels in TeadF/F TM diet and Tead1-icKO hearts (n = 4). (C) I-1 and PP1 catalytic unit (PP1c) protein levels in control and Tead1-icKO hearts. (D) ChIP with control mouse IgG (mIgG) and TEAD1 antibody (n = 3). The presence of mPpp1r1a (I-1) promoter regions were detected by qPCR. I-1 promoter luciferase assay in (E) Tead1-KO (Cre-AdV) and control (lacZ-AdV) Tead1-flox NCMs and (F) H9c2 rat cardiomyoblasts. ***P < 0.001, **P < 0.01, *P < 0.05; P values were determined using Student’s t test.