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(A) Schematic of bone marrow transplant experiment. Fifteen WT and 17 Mtg16–/– mice were irradiated, transplanted with WT bone marrow, allowed to recover 12 weeks, and followed by azoxymethane/dextran sodium sulfate (AOM/DSS) inflammatory carcinogenesis protocol. (B) Mtg16–/– and WT mouse tumor multiplicity (WT = 12, Mtg16–/– = 16) and (C) size (WT = 11, Mtg16–/– = 15). Student’s t test, ***P < 0.001.
