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. 2017 Sep 7;2(17):e92321. doi: 10.1172/jci.insight.92321

Figure 5. Podoplanin is expressed on non–IL-17–secreting T cells in Candida skin infections.

Figure 5

(A) Brightfield staining with anti-CD3 shows several lymphocytic infiltrates within the dermis. Counterstained with hematoxylin. Scale bar: 100 μm. (B) Immunofluorescent staining with antibodies against CD3 (gray), PDPN (red), and IL-17 (cyan) shows PDPN+CD3+ lymphocytes and IL-17+CD3+ lymphocytes but no double-positive (PDPN+/IL-17+) CD3+ lymphocytes (magnified ×1.8 in C and D). Blue: Hoechst Dye 33342 (nuclear stain). Scale bar: 45 μm. (E) Quantification of PDPN+ and IL-17+ CD3+ lymphocytes in n = 4 cases of cutaneous candidiasis.