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. 2017 Sep 7;2(17):e94387. doi: 10.1172/jci.insight.94387

Figure 2. Characteristics of HERV-W-Env expression in pancreas and during the course of the disease.

Figure 2

(A) Three nPOD T1D cases stained with GN_mAb_Env03 are presented at 0.5× original magnification, and corresponding higher magnification 3× and 10×. nPOD case ID, block number, and pancreas zone are indicated on the left, and disease duration is indicated on the right. Scale bars: 0.5 ×, 5mm; 3×, 500 μm; 10×, 250 μm. (B–D) For each of the 3 cohorts presented in Figure 1, A–C, HERV-W-Env expression is presented as a function of the disease duration, the dotted line representing the positivity cutoff. T1D duration is presented as function of HERV-W-Env protein expression in serum as determined by ELISA (B), as a function of HERV-W-env gene expression in PBMC (C), or as a function of HERV-W-Env expression in pancreas as determined by IHC (D).