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. 2017 Sep 7;2(17):e90874. doi: 10.1172/jci.insight.90874

Figure 4. Treatment with intermittent PTH prolongs survival in mice undergoing tumor debulking surgery.

Figure 4

(A) Survival model 1 experimental design (n = 10). Mice were 10 weeks old at the time of tumor cell injections (B) Kaplan-Meier plots to assess survival after debulking of primary tumors in model 1. Median survival of PBS-treated mice was 19 days and that of PTH-treated mice was 25 days (P = 0.0183, log-rank [Mantel-Cox] test). (C) Survival model 2 experimental design (n = 10). (D) Kaplan-Meier plots to assess survival after debulking of primary tumors in model 2. Median survival of PBS-treated mice was 30 days and that of PTH-treated mice was 36 days (P = 0.029, log-rank [Mantel-Cox] test). (E) Representative BLI imaging of skeletal and other distal organs at end point. (F) H&E staining (areas of tumor are indicated with arrows) and (G) macroscopic examination of lungs at end point from mice in survival model 2 at end point. Scale bar: 200 μm. All values represent mean ± SD for each group.