Figure 1. Association between Aire and antimelanoma effects of CTLA-4 blockade in mice and humans.
(A and B) WT and AireGW/+ mice were s.c. injected with 1 × 105 B16 melanoma cells followed by anti–CTLA-4 (aCTLA-4) antibody or isotype control (iso) antibody treatment. Mice in each group were followed for B16 melanoma tumor growth and survival. n = 7–12 per group, cumulative of at least 2 independent experiments. Mann-Whitney U test. *P < 0.05. (C and D) Comparison of progression-free survival (PFS) and overall survival (OS) probability between patients with Aire SNP rs1055311 (TT versus CT/CC).