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. 2017 Sep 21;2(18):e93265. doi: 10.1172/jci.insight.93265

Figure 4. Additive antimelanoma effect of Aire deficiency and anti–CTLA-4 antibody in TRP-1 CD4+ TCR Tg mice.

Figure 4

(A and B) Aire sufficient (WT) and AireGW/+ TRP-1 TCR Tg mice were s.c. injected with 1 × 105 B16 melanoma cells followed by anti–CTLA-4 antibody (aCTLA-4) or isotype control antibody (Iso) treatment, as outlined. Mice in each group were followed for B16 melanoma tumor growth (A) and survival (B). n = 7–12 per group, cumulative of at least 2 independent experiments. Mann-Whitney U test. *P < 0.05. (C) Examples of periporbital and tail vitiligo in AireGW/+ mice treated with aCTLA-4 antibody.