Figure 8. REV-ERB agonist prevented the endothelin-1–induced (ET-1–induced) hypertrophy in human induced pluripotent stem cell–differentiated cardiomyocytes (iPS-CM).

iPS-CM were pretreated with vehicle or SR9009 for 24 hours and then treated with ET-1 for 48 hours. qPCR of Nppb. *P = 0.01 (untreated), **P = 0.003 (ET-1), n = 3. Statistical differences were determined by 2-tailed Student’s t test. Data are presented as mean ± SEM. Multiple comparison is corrected for by using Holm-Sidak method, with α = 0.05.