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. 2017 Sep 21;2(18):e95530. doi: 10.1172/jci.insight.95530

Figure 5. Intravitreous injection of a VEGF-neutralizing protein causes opening of some vessels closed by chronic overexpression of VEGF in the retinas of rho/VEGF mice.

Figure 5

Fluorescein angiography (FA) was done on 7-month-old rho/VEGF mice (A), and then the mice were given subcutaneous injections of 25 mg/kg aflibercept every other day for a total of 4 injections followed by repeat FA (B). At baseline prior to aflibercept injection, several black areas devoid of fluorescein were seen, indicating closure of retinal vessels (A, asterisks and dots within boxes). After aflibercept injections, many of the nonperfused areas were perfused indicating opening of previously closed vessels (B, boxes). Comparison of a magnified view of the large white box in A (C) with a magnified view of box in B, the same region of the retina after aflibercept treatment (D), shows 4 black regions devoid of blood vessels (C, asterisks) in which vessels reappear after aflibercept treatment indicating reopening (D). However, other black areas (dots) remain black after aflibercept treatment indicating that not all closed vessels reopen.