Figure 1. Acute uncomplicated malaria is associated with a robust proinflammatory cytokine response and systemic inflammation.

Plasma cytokine and acute-phase reactant levels were compared in samples from cases of acute uncomplicated malaria and 6-week recovery samples (n = 60 pairs) and samples from heathy child controls (n = 40). Bars represent medians with interquartile ranges. Wilcoxon matched-pairs rank test was used to compare acute malaria samples to 6-week recovery samples. Kruskal-Wallis test was used to compare healthy child samples to acute malaria and 6-week recovery samples. ****P < 0.0001. IP-10, IFN-γ–induced protein 10.