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Naive CD4+ T cells, which do not express IL-23R, fail to respond to IL-23. Both IL-6 and IL-12 induce the initial expression of IL-23R. IL-23 signaling further promotes the expression of IL-23R and consequently enhances the sensitivity of IL-23 on those cells. IL-23 signals via p-STAT3/p-STAT4 heterodimers, which might regulate genes contributing to the encephalitogenicity.
