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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Trends Biochem Sci. 2017 Aug 4;42(10):799–811. doi: 10.1016/j.tibs.2017.07.002

Figure 1. Kinase domain architecture and dynamics.

Figure 1

The αC helix in all structures is in lime color, adjacent αC-β4 loop is in red. The proteins have been aligned by the αE helix (salmon color helix in C-lobe). Arrows show the direction and relative magnitude of N-lobe motion in relation to C-lobe. (A) Structures of EGFR in the active state (light blue in color, PDB:2ITP) and the inactive state (piper in color, PDB:2GS7). Note the small shift in αC helix between states. (B) Snapshot from 12us all-atom MD simulation on EGFR from Shaw group displaying an opening between the kinase lobes. (C) Cdk4 kinase structure as it is in the cryoEM complex of Hsp90-Cdc37-Cdk4 (PDB:5FWL) showing dramatic unfolding between the kinase lobes and unraveling of β4- β5 strands.

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