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. 2017 Sep 29;7:12452. doi: 10.1038/s41598-017-12717-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nociceptive behavior evoked by i.pl. injection of resiniferatoxin (RTX test) and the inhibitory effect of capsazepine. (a) Time course of licking/biting behavior evoked by i.pl. injection of RTX (0.01-100 ng). RTX was injected at time zero (arrowhead). For clarity, the results for 0.01, 0.1 and 10 ng RTX are not shown. (b) Time spent licking/biting during the first 10 minutes of the test. (c, d) Time course of licking/biting behavior evoked by i.pl. injection of RTX (1 ng) and time spent licking/biting during the first 10 minutes of the test. Capsazepine was co-injected with RTX at time zero (arrowhead in c). All data represent the mean ( ± SEM) result from six and five mice in (a, b) and (c, d) respectively. Non-parametric multiple comparisons with Bonferroni correction following the Kruskal-Wallis test were used [(b), five comparisons in six groups; (d), three comparisons in four groups; *P < 0.05 vs. Vehicle group]. CZP, capsazepine; i.pl., intraplantar injection.