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. 2017 Sep 29;7:12452. doi: 10.1038/s41598-017-12717-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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I.c.v. administration of RTX spares the function of TRPV1 at the hindpaw. Mice were pretreated with RTX one week before the tests [(a, b, g) s.c. pretreatment; (c, d) i.t. pretreatment; (e, f, h) i.c.v. pretreatment]. Time course of licking/biting behavior evoked by i.pl. injection of RTX (1 ng to the hindpaw, arrowheads in a, c, e) and total time spent licking/biting during the first 10 minutes of the tests. (g, h) Time spent licking/biting behavior in response to i.pl. injection of 0.3% H₂O₂. All data represent the mean ± SEM. The number of mice in each group is shown in parentheses. The Mann-Whitney U-test was used (*P < 0.05). i.pl., intraplantar injection.