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. 2017 Sep 29;7:12452. doi: 10.1038/s41598-017-12717-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analgesic effect of acetaminophen in the formalin test and the tail pressure test in RTX-i.c.v.-pretreated mice. Mice were pretreated with RTX (100 ng, i.c.v.) or vehicle one week before the tests. (a) Time course of licking/biting behavior evoked by i.pl. injection of 2.5% formalin (arrowhead). Acetaminophen was i.p.-administered 20 min before formalin injection. (b, c) The first and second phases recorded during 0-10 and 10-50 min after injection of formalin, respectively. (d) Change in the threshold for acute mechanical nociception. Acetaminophen was i.p.-administered at time zero (arrowhead). All data represent the mean ± SEM. The number of mice in each group is shown in parentheses. The Mann-Whitney U-test was used for b-d (*P < 0.05 vs. Vehicle-i.c.v. group). AcAP, acetaminophen; PG, propyleneglycol; n.s., not significant; i.pl., intraplantar injection.