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. 2017 Sep 29;7:12412. doi: 10.1038/s41598-017-12603-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially vulnerable synaptic population molecular profiling. (a) Venn diagram and heat map show the 709 common proteins identified and overlapped in cortical, hippocampus and thalamic synaptic proteomic datasets. (B) Heat map representing the significance (−log P value) of the canonical pathways identified in IPA across cortex, hippocampus and thalamus datasets. It is observed a preogressive increase in significance correlating to the synaptic vulnerability pattern described previously. (C) Heat map showing the 709 common proteins identified and overlapping in cortical, hippocampus and thalamic synaptic proteomic datasets. (D) BioLayout clustering 3D representation of proteomic expression data across differentially vulnerable synaptic populations orientated at 3 different angles. Each sphere represents a single protein and the edge represents how similar their expression trend is towards the other proteins in the dataset. The closer the spheres are the more similar expression trend they have. The colours represent the different clusters of co-expressed proteins. (E) Expression profile means in log scale (Cln3 ^−/− /WT) of co-expressed proteins in clusters 3, 4, 6 and 7 (Supplementary Tables S1) and its main biological function/subcellular compartment identified by DAVID enrichment analysis (See Supplementary Table S2). Clusters highlighted show steady up or downregulation across cortex (C), hippocampus (H) and thalamic (T) regions correlating with the vulnerability status of synapses.