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. 2017 Sep 29;7:12409. doi: 10.1038/s41598-017-12635-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of MB on inflammasome model animals and non-canonical inflammasome. (A) Mice (n = 10 per group) were intraperitoneally (ip) injected with LPS (25 mg/Kg) and/or MB as indicated. Survival rates were observed at the indicated times. (B and C), Mice (n = 5 per group) were ip-injected with LPS (4 mg/kg) and/or MB (500 μg/mouse). IL-1β (B) and IL-6 (C) secretion levels in peritoneal lavage fluids were measured. (D and E), Mice (n = 9 per group) were ip injected with Listeria monocytogenes (1,000 cfu in 200 μL of saline) and/or MB (500 μg/mouse). Number of peritoneal exudate cells (PECs, B) was calculated, and IL-1β (C) secretion levels of peritoneal lavage fluids were measured. Bar graph presents the mean ± SD.