Table 2.

The genotypes and allele frequencies of three TLR7 SNPs in patients with CHB, LC and HCC combined (cases) and controls.

Genotypes and allele frequencies	Cases, No (%)	Controls, No (%)	OR(95%CI)	P value
Male	No = 419	No = 195
TLR7 rs179010 major allele C	286(68.3)	116(59.5)	1	Reference
TLR7 rs179010 minor allele T	133(31.7)	79(40.5)	0.818(0.683–0.979)	0.029
Female	No = 193	No = 98
TLR7 rs179010 CC	82(42.5)	46(46.9)	1	Reference
TLR7 rs179010 CT	85(44)	45(45.9)	0.944(0.566–1.573)	0.824
TLR7 rs179010 TT	26(13.5)	7(7.1)	0.480(0.193–1.192)	0.108
TLR7 rs179010 major allele C	249(64.5)	137(69.9)	1	Reference
TLR7 rs179010 minor allele T	137(35.5)	59(30.1)	0.783(0.541–1.133)	0.193
Male	No = 419	No = 195
TLR7 rs2074109 major allele T	395(94.3)	185(94.9)	1	Reference
TLR7 rs2074109 minor allele C	24(5.7)	10(5.1)	0.890(0.417–1.899)	0.762
Female	No = 193	No = 98
TLR7 rs2074109 TT	167(86.5)	85(86.7)	1	Reference
TLR7 rs2074109 CT	24(12.4)	13(13.3)	1.064(0.516–2.194)	0.866
TLR7 rs2074109 CC	2(1.1)	0	/	0.553
TLR7 rs2074109 major allele T	358(92.7)	183(93.4)	1	Reference
TLR7 rs2074109 minor allele C	28(7.3)	13(6.6)	0.908(0.459–1.795)	0.782
Male	No = 419	No = 195
TLR7 rs179009 major allele A	347(82.8)	167(85.6)	1	Reference
TLR7 rs179009 minor allele G	72(17.2)	28(14.4)	0.808(0.503–1.298)	0.378
Female	No = 193	No = 98
TLR7 rs179009 AA	130(67.4)	75(76.5)	1	Reference
TLR7 rs179009 AG	56(29)	20(20.4)	0.619(0.345–1.110)	0.106
TLR7 rs179009 GG	7(3.6)	3(3.1)	0.743(0.187–2.959)	0.931
TLR7 rs179009 major allele A	316(81.9)	170(86.7)	1	Reference
TLR7 rs179009 minor allele G	70(18.1)	26(13.3)	0.690(0.424–1.124)	0.135

P value was adjusted for age by logistic regression between cases and controls.