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. 2017 Sep 29;7:12444. doi: 10.1038/s41598-017-12691-y

Table 5.

Sensitivity Analysis.

Parameter Description Baseline 10 fold increase 10 fold decrease % Change in Steady State
10 fold increase 10 fold decrease
Ka Aggregation Constant
avb3 (vWF) Aggregate Receptor Pair 0.0014422 0.0001595 0.00731635 −88.9417 4.07317
Single Divalent Receptor 0.047071 0.0496846 0.03206668 0.0555246 −31.8759
avb3 (Fn) Aggregate Receptor Pair 0.0025167 0.0003024 0.00916465 −87.9828 2.64149
Single Divalent Receptor 0.0448266 0.0494085 0.0250326 0.102215 −44.1568
a1b1 (Col I) Aggregate Receptor Pair 7.787 × 10−10 7.788 × 10−11 7.7855 × 10−9 −89.9997 899.743
Single Divalent Receptor 0.0001 0.0001 9.9988 × 10−5 1.4009 × 10−5 −0.0001401
Kp Population of Empty Paired Receptors
avb3 (vWF) Aggregate Receptor Pair 0.0014422 0.0012618 0.00144284 −12.5058 0.0466698
Single Divalent Receptor 0.047071 0.0470725 0.04706991 0.00319051 −0.0022229
avb3 (Fn) Aggregate Receptor Pair 0.0025167 0.0022089 0.00252032 −12.2318 0.142716
Single Divalent Receptor 0.0448266 0.0448329 0.04482091 0.0140776 −0.0126299
a1b1 (Col I) Aggregate Receptor Pair 7.787 × 10−10 7.489 × 10−10 7.7875 × 10−10 −3.83664 −4.768 × 10−5
Single Divalent Receptor 0.0001 0.0001 0.0001 −2.454 × 10−8 −1.34 × 10−10
Kx Aggregate Receptor Saturation
avb3 (vWF) Aggregate Receptor Pair 0.0014422 0.0010941 0.00144273 −24.1374 0.03937633
Single Divalent Receptor 0.047071 0.0470717 0.04707014 0.00154618 −0.0017387
avb3 (Fn) Aggregate Receptor Pair 0.0025167 0.0019215 0.00251985 −23.650441 0.12406835
Single Divalent Receptor 0.0448266 0.0448308 0.04482188 0.00949427 −0.0104646
a1b1 (Col I) Aggregate Receptor Pair 7.787 × 10−10 7.06 × 10−10 7.7875 × 10−10 −9.3388012 −7.855 × 10−5
Single Divalent Receptor 0.0001 0.0001 0.0001 −4.37 × 10−9 −2.26 × 10−10
Ki Integrin Complex Formation
avb3 (vWF) Aggregate Receptor Pair 0.0014422 0.0142873 2.8307 × 10−5 890.686233 −98.03722
Single Divalent Receptor 0.047071 0.0306523 0.04969114 −34.880649 5.56644996
avb3 (Fn) Aggregate Receptor Pair 0.0025167 0.0206362 5.2505 × 10−5 719.962077 −97.91377
Single Divalent Receptor 0.0448266 0.0236912 0.04943082 −47.14931 10.2712401
a1b1 (Col I) Aggregate Receptor Pair 7.787 × 10−10 9.496 × 10−9 1.3021 × 10−11 1119.42405 −98.327913
Single Divalent Receptor 0.0001 9.694 × 10−5 1 × 10−4 −3.0666187 −0.0017795
Kc Single Divalent Receptor Saturation
avb3 (vWF) Aggregate Receptor Pair 0.0014422 0.0002512 0.00269898 −82.584496 87.1478824
Single Divalent Receptor 0.047071 0.0426039 0.04702548 −9.4901208 −0.0966041
avb3 (Fn) Aggregate Receptor Pair 0.0025167 0.0004241 0.00482601 −83.148576 91.7572123
Single Divalent Receptor 0.0448266 0.0410334 0.04467362 −8.4619004 −0.3412082
a1b1 (Col I) Aggregate Receptor Pair 7.787 × 10−10 1.279 × 10−10 1.2887 × 10−9 −83.571112 65.4777672
Single Divalent Receptor 0.0001 9.695 × 10−5 9.9998 × 10−5 −3.0532152 −0.003242

Sensitivity Analysis for Integrin Receptor Concentration. Sensitivity analysis was performed by modulating equilibrium binding constants, calculating the percent change in steady state value attained by the system. Values for CCl4 treatment groups used for analysis.