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. 2017 Sep 29;8:750. doi: 10.1038/s41467-017-00833-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — cGAS inhibition by RU.365 and its chemical active analogs. a In vitro concentration response curves for RU.365 and the most potent analog synthesized in-house, RU.521, in the presence of dsDNA, ATP and GTP as measured by RF-MS. The IC50 values for RU.365, RU.521 and less potent analogs are listed in Supplementary Table 4. Values are averages of triplicate determinations with SD indicated. b Isothermal titration calorimetry-binding curves for RU.521 titrated into cGAS/dsDNA complex