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. 2017 Sep 29;8:750. doi: 10.1038/s41467-017-00833-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Small-molecule inhibition of cGAS-dependent interferon induction in cellular assays. RU.365, RU.332, and RU.521 were tested in cellular assays for their effectiveness in inhibiting cGAS activity in dsDNA-stimulated RAW macrophages. The inhibition of type I IFN response via dsDNA was monitored via an interferon sensitive promoter coupled to a luciferase gene. The concentration response curves for RU.365 (a), RU.332 (b), and RU.521 (c) in RAW cells are shown. Error bars represent SEM