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. 2017 Sep 29;7:12440. doi: 10.1038/s41598-017-12124-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolic features of the RIP-DTR mouse. (a,b) Unfasted blood glucose levels (a) and 4 hours fasted plasma insulin levels (b) measured daily following diphtheria toxin (solid line) or sham treatment (dashed line) of RIP-DTR mice. Control, n = 10 and DT, n = 5. (c,d) Graphs of glucose tolerance tests performed one week before and 40 hours after DT treatment of RIP-DTR positive and negative mice of mixed genders. Area under the curve (A.U.C.) was calculated, showing a significant difference 40 hours after treatment. Control, n = 9 and DT, n = 13. Data presented as mean ± SE. Statistical significance indicated as ^*P < 0.05, ^**P < 0.01, ^***P < 0.001. n.s.: nonsignificant.