Table 4.

Coupled substitutions in start codons and neighboring sequences.

Paired with a single substitution at position	Start codon substitutions	All other substitution	Frequency	p-value of comparison to all other positions	p-value of comparison to −1 to −3	p-value of comparison to −7 to −10
−7 to −10	80	9741	0.0082	5.2 × 10−4	0.61	—
−1 to −3	118	15529	0.0076	6.7 × 10−4	—	0.61
All other positions	405	76884	0.0053	—	6.7 × 10−4	5.2 × 10−4