Table 2. Top-ranked results from the meta-analysis of SNP-based associations for facet-level traits of neuroticism.

Facet	SNP	Chr	Position	Effect allele	MAF	Z-score	P-value	Directiona	HetChiSq	HetPval	Nearest Geneb
N1	rs78773901	2	188731477	C	0.027	−4.665	3.09E-06	−−	3.571	0.168	.
	rs4685767	3	4613530	G	0.361	4.506	6.59E-06	+++	0.404	0.817	ITPR1
	rs2700687	7	33666459	A	0.362	−4.493	7.03E-06	−−	0.819	0.664	BBS9
	rs9316411	13	49321854	G	0.079	−4.445	8.78E-06	−−	3.469	0.177	CYSLTR2
	rs10970114	9	31116845	A	0.221	−4.424	9.70E-06	−−	0.877	0.645	.
N2	rs1360001	9	78259530	T	0.168	5.878	4.14E-09	+++	4.434	0.109	MIR548H3
	rs74627388	3	13888606	T	0.113	4.841	1.29E-06	+++	0.822	0.663	WNT7A
	rs75400032	2	35295043	A	0.192	4.718	2.38E-06	+++	0.325	0.850	.
	rs117920056	5	149128924	T	0.024	4.683	2.83E-06	+++	0.111	0.946	PPARGC1B
	rs12187180	5	20815506	G	0.286	4.524	6.08E-06	+++	0.572	0.751	.
N3	rs2929855	5	44390364	A	0.133	−4.591	4.41E-06	−−	4.919	0.085	FGF10
	rs1007107	6	14463419	G	0.389	4.515	6.32E-06	+++	0.648	0.723	.
	rs11242622	5	106373992	T	0.308	−4.501	6.75E-06	−−	1.614	0.446	LOC102467213
	rs10151594	14	51864477	A	0.099	−4.491	7.08E-06	−−	0.044	0.978	LINC00640
	rs17257269	3	60025505	C	0.025	4.485	7.29E-06	+++	0.879	0.644	FHIT
N4	rs308254	13	93672943	T	0.287	−4.822	1.43E-06	−−	1.283	0.527	.
	rs79425212	6	30813282	A	0.203	4.811	1.51E-06	+++	3.195	0.202	DDR1
	rs145239798	2	188754537	A	0.026	−4.736	2.18E-06	−−	2.235	0.327	.
	rs11691878	2	22021330	C	0.166	−4.656	3.22E-06	−−	0.036	0.982	LOC645949
	rs75769602	13	61788256	C	0.051	4.603	4.16E-06	+++	1.758	0.415	MIR3169
N5	rs114649649	1	201299361	A	0.063	−4.896	9.79E-07	−−	1.589	0.452	PKP1
	rs12494147	3	11668983	T	0.060	4.663	3.11E-06	+++	1.567	0.457	VGLL4
	rs7967431	12	82342828	C	0.415	−4.636	3.55E-06	−−	7.932	0.019	LOC101928449
	rs4569911	5	160235125	T	0.469	−4.562	5.06E-06	−−	0.059	0.971	ATP10B
	rs1093307	12	117925643	T	0.190	4.498	6.86E-06	+++	0.260	0.878	KSR2
N6	rs2784611	9	10551203	A	0.442	4.521	6.17E-06	+++	1.031	0.597	PTPRD
	rs17495034	1	222181354	C	0.138	4.459	8.22E-06	+++	2.229	0.328	.
	rs12944395	17	28323499	G	0.395	4.414	1.02E-05	+++	0.498	0.780	EFCAB5
	rs183360621	2	36464282	A	0.015	4.412	1.03E-05	+++	0.151	0.928	.
	rs58450504	3	72555840	G	0.174	−4.379	1.19E-05	−−	0.752	0.687	RYBP

Abbreviations: Chr, chromosome; HetChiSq, heterogeneity chi-square statistic; HetPval, heterogeneity P-value; MAF, minor allele frequency; N1, anxiety; N2, angry hostility; N3, depression; N4, self-consciousness; N5, impulsivity; N6, vulnerability; SNP, single-nucleotide polymorphism.

^aDirection is described the SNP beta-coefficient from Ansan Ansung, Kangbuk Samsung and Young Women cohort in sequence.

^bNearest genes are defined as the closest genes to the SNP within signal boundary or the closest genes within a 100 kb window.