Table 3. Significant results from meta-analysis of pathway-based associations for facet-level traits of neuroticism.
| Facet | DB | Pathway | Meta-pa |
Nominal p |
||
|---|---|---|---|---|---|---|
| AS | KS | YW | ||||
| N1 | REACTOME | Platelet activation signaling and aggregation | 4.50E-06 | 2.80E-03 | 1.00E-04 | 2.36E-02 |
| REACTOME | Developmental biology | 9.19E-06 | 7.40E-03 | 8.10E-05 | 1.10E-03 | |
| REACTOME | Signaling by rho GTPases | 2.05E-05 | 5.66E-02 | 2.50E-05 | 4.00E-02 | |
| KEGG | Focal adhesion | 9.77E-05 | 7.64E-02 | 1.00E-04 | 4.70E-03 | |
| KEGG | Glioma | 1.17E-04 | 9.26E-02 | 1.00E-04 | 2.08E-01 | |
| N2 | KEGG | Focal adhesion | 1.45E-07 | 4.00E-05 | 1.84E-04 | 2.99E-02 |
| REACTOME | Collagen formation | 1.01E-06 | 3.00E-03 | 1.90E-05 | 3.90E-03 | |
| REACTOME | Axon guidance | 2.10E-06 | 1.13E-04 | 1.10E-03 | 1.00E-04 | |
| REACTOME | NCAM signaling for neurite outgrowth | 7.03E-06 | 3.00E-04 | 1.50E-03 | 3.00E-04 | |
| REACTOME | Developmental biology | 1.13E-05 | 2.50E-03 | 3.00E-04 | 1.10E-03 | |
| KEGG | ECM receptor interaction | 5.91E-05 | 4.98E-04 | 8.90E-03 | 4.01E-02 | |
| N3 | KEGG | Focal adhesion | 7.21E-07 | 4.00E-04 | 1.00E-04 | 6.50E-05 |
| REACTOME | Integrin cell surface interactions | 1.37E-06 | 7.89E-02 | 1.00E-06 | 5.45E-02 | |
| KEGG | ECM receptor interaction | 5.88E-06 | 7.30E-05 | 5.10E-03 | 7.80E-03 | |
| REACTOME | Collagen formation | 4.75E-05 | 1.00E-03 | 3.50E-03 | 7.22E-02 | |
| N4 | REACTOME | Axon guidance | 1.71E-06 | 5.00E-04 | 2.00E-04 | 9.90E-07 |
| REACTOME | CA dependent events | 5.84E-05 | 2.19E-02 | 2.00E-04 | 8.66E-01 | |
| REACTOME | DAG and IP3 signaling | 6.72E-05 | 1.02E-02 | 5.00E-04 | 9.02E-01 | |
| N5 | KEGG | Renal cell carcinoma | 2.04E-04 | 1.30E-03 | 1.31E-02 | 2.18E-01 |
| N6 | REACTOME | Axon guidance | 4.31E-05 | 1.00E-04 | 3.15E-02 | 6.40E-03 |
| REACTOME | SLC-mediated transmembrane transport | 5.01E-05 | 2.21E-02 | 1.68E-04 | 3.09E-02 | |
| REACTOME | CRMPS in SEMA3A signaling | 6.50E-05 | 3.30E-05 | 1.49E-01 | 5.52E-02 | |
Abbreviations: AS, Ansan Ansung cohort; KS, Kangbuk Samsung cohort; N1, anxiety, N2, angry hostility, N3, depression, N4, self-consciousness, N5, impulsivity, N6, vulnerability; YW, Young women cohort.
aCombined nominal P-value of three cohorts were calculated by Fisher’s method.
a
Significance thresholds for pathway-based meta-analysis were determined separately for each database (KEGG: 0.05/186=2.69 × 10−4; REACTOME: 0.05/674=7.42 × 10−5).