Table 1. Fourteen loci reaching genome-wide significance for association with alcohol consumption in UKB after performing clump-based LD pruning.
| SNP | CHR | POS | A1/A2 | Freq | β (s.e.) | P | Genes |
|---|---|---|---|---|---|---|---|
| rs145452708 | 4 | 100248642 | C/G | 0.01 | −0.034 (0.003) | 1.15 × 10−30 | ADH1B/ADH1C |
| rs193099203 | 4 | 99630017 | T/C | 0.007 | −0.031 (0.003) | 3.79 × 10−25 | — |
| rs1260326 | 2 | 27730940 | T/C | 0.39 | −0.028 (0.003) | 1.34 × 10−21 | GCKR |
| rs11940694 | 4 | 39414993 | A/G | 0.39 | −0.027 (0.003) | 8.4 × 10−19 | KLB |
| rs29001570 | 4 | 99994405 | C/T | 0.006 | −0.026 (0.003) | 9.58 × 10−19 | ADH5 |
| rs3114045 | 4 | 100252560 | T/C | 0.13 | −0.020 (0.003) | 7.98 × 10−12 | ADH1B/ADH1C |
| rs140280172 | 4 | 100832564 | A/C | 0.005 | −0.020 (0.003) | 2.89 × 10−11 | DNAJB14 |
| rs9841829 | 3 | 85569361 | G/T | 0.23 | 0.019 (0.003) | 3.36 × 10−10 | CADM2 |
| rs35081954 | 4 | 100270818 | CTG/C | 0.42 | 0.018 (0.003) | 2.14 × 10−9 | ADH1C |
| rs375507729 | 3 | 85062293 | T/TAA | 0.44 | 0.018 (0.003) | 3.19 × 10−9 | CADM2 |
| rs9991733 | 4 | 39420994 | G/A | 0.28 | 0.018 (0.003) | 3.80 × 10−9 | KLB |
| rs149127347 | 4 | 99101007 | G/T | 0.003 | −0.018 (0.003) | 4.42 × 10−9 | — |
| rs145329623 | 4 | 98528709 | G/A | 0.003 | −0.017 (0.003) | 5.68 × 10−9 | STPG2 |
| 18:72124965 | 18 | 72124965 | CCTCCCG/C | 0.05 | 0.017 (0.003) | 2.18 × 10−8 | FAM69C |
Abbreviations: CHR, chromosome; Freq, A1 frequency; GWAS, genome-wide association study; LD, linkage disequilibrium; POS, base pair position; SNP, single-nucleotide polymorphism; UKB, UK Biobank.
Genes are reported if SNPs located ±10 kb of the locus. SNPs highlighted as bold represent completely independent associations identified by conditional SNP analyses.