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. 2017 Sep 29;7:12432. doi: 10.1038/s41598-017-12810-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Survival, weight and food and water consumption. (A) Survival curve of VMAT2^lox/lox mice bilaterally injected with AAV2-GFP (n = 7) or AAV2-CRE-GFP (n = 8) in the SN (Log-rank (Mantel-Cox) test: p < 0.001). (B) Weight curve of VMAT2^lox/lox mice bilaterally injected with AAV2-GFP (n = 13) or AAV2-CRE-GFP (n = 11) in the SN (Mann-Whitney U: AAV2-GFP vs AAV2-CRE-GFP: Week 0: p = 0.91; Week 4: p = 0.91; Week 8: p = 0.88; Week 12: p = 0.43; Week 16: **p < 0.01). (C) Food and water consumption of VMAT2^lox/lox mice bilaterally injected with AAV2-GFP (n = 7) or AAV2-CRE-GFP (n = 7) in the SN at 8 and 16 weeks’ post-virus injection (Mann-Whitney U: AAV2-GFP vs AAV2-CRE-GFP: Food consumption: Week 8: p = 0.14; Week 16: *p < 0.05; Water consumption: Week 8: p = 0.53; Week 16: **p < 0.01). SN: Substancia nigra, VMAT2: Vesicular Monoamine Transporter-2, AAV: Adenoassociated Virus.