Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 29;7:12432. doi: 10.1038/s41598-017-12810-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Neuroanatomical consequences of nigrostriatal DA depletion. (A) Illustration of D2 (left) and DAT (right) mRNA radioactive in situ labelling in the SN and the VTA. (B) Density (nCi/mg) of D2 (left) and DAT (right) mRNA expression in the SN and VTA, measured by radioactive in situ hybridization, 16-week after AAV2-GFP or AAV2-CRE-GFP bilateral injection in VMAT2^lox/lox mice (n = 4 per groups, Mann-Whitney U: AAV2-GFP vs AAV2-CRE-GFP: D2: SN *p < 0.05; VTA *p < 0.05; DAT: SN p = 0.47; VTA p = 0.14). (C) Illustration of TH immunostaining in DA neurons of the SN and the VTA (Left) and in the fibers in the CPu and NAc (Right). (D) Number of TH positive cell per mm2 in the SN and the VTA (Left) and optic density of TH positive fibers in the CPu and the NAc (Right) 16-week after AAV2-GFP or AAV2-CRE-GFP bilateral injection in VMAT2^lox/lox mice (n = 4 per groups, Mann-Whitney U: AAV2-GFP vs AAV2-CRE-GFP: TH + cells: SN p = 0.59; VTA p = 0.38; optic density: CPu p = 0.86; NAc p = 0.6). SN: Substancia nigra, VTA: Ventral Tegmental Area, CPu: Caudate Putamen, NAc: Nucleus Accumbens, PFC: PreFrontal Cortex, VMAT2: Vesicular Monoamine Transporter-2, AAV: Adenoassociated Virus, TH: Tyrosine hydroxylase.