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(A) Flexibility of cell-penetrating peptide (CPP) incorporation into the Ab scaffold. Some examples efficiently passed through the BBB (18, 36, 44). The yellow color indicates CPP and the blue color indicates Abs. (B) CPPs can mediate RMT by binding receptor at the BBB and transporting the Ab across the cytosol to the other side of the BBB. (C) CPPs consisting of amphipathic and/or cationic sequences can mediate AMT and allow crossing the BBB.
