Table 3.

Effects of antipsychotic drugs on expression of Nrg1 and ErbB4 signaling.

	Subjects	Drugs	Dosage	Treatment duration	Nrg1/ErbB4	Reference
Human studies	PBL cells	Clozapine/ Haloperidol	2 μM/500 nM	3 weeks	Up/No changes	Chana et al., 2009
	Onset patients	Risperidone/ Quetiapine	(533.33±71.45)mg/ day/(544.62±63.85) mg/day	4 weeks	Up/Up	Zhang et al., 2008
Animal studies	Rat	Haloperidol/ Risperidone/ Clozapine	1 mg/kg i.p./1 mg/kg i.p./ 10 mg/kg i.p.	4 weeks	Up/Up/Down	Wang Y.C. et al., 2008
	Monkey	Haloperidol	0.125–0.25 mg/mL/day	8 weeks	No changes	Shibuya et al., 2010
	Mice	Haloperidol	2 mg/kg/day	12 weeks	Down	Hahn et al., 2006
	Rat	Aripiprazole/ Olanzapine/ Haloperidol	UN	12 weeks	Down/Down/Down	Pan et al., 2011

Up, Up Regulation; Down, Down Regulation; PBL, Peripheral Blood Lymphocytes; UN, Unknown.