Table 1.
Function | miRNAs involved | Known targets/pathways |
---|---|---|
Angiogenesis | miR-16, miR-29 | Vascular endothelial growth factor (VEGF)-A |
miR-494 | CDK6/CYCD1 | |
miR-17 miR-20a, miR-20b | Ephrin B2, B4 | |
miR-125b-1-3p | S1PR | |
miR-155 | CYR 6, VEGF-A | |
miR-21 | PTEN, positive regulator of VEGF-A and HIF-1α | |
miR-210 | EFNA3, HOXA9, HSD17 | |
Trophoblast proliferation | miR-16, miR-29b | Inhibits trophoblast proliferation |
miR-34a | SERPINA3 | |
miR-210 | KCMF-1 | |
miR-155 | CYCD1 | |
miR-378a-5p, miR-376c, miR-21 | Promotes trophoblast proliferation by nodal signaling pathway | |
miR-17-92 cluster | Differentiation of primary trophoblasts | |
Inflammation | miR-146a | Inflammatory pathway |
miR-155 | IL-17A pathway | |
miR-494 | Macrophage proliferation by reducing PGE2 production | |
miR-181a | TGFβ pathway | |
miR-152 | HLA-G | |
miR-210 | STAT6/IL-4 pathway |