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. 2017 Sep 25;4:60. doi: 10.3389/fcvm.2017.00060

Table 1.

A list of placenta-associated microRNAs (miRNAs) involved in preeclampsia (PE).

Function miRNAs involved Known targets/pathways
Angiogenesis miR-16, miR-29 Vascular endothelial growth factor (VEGF)-A
miR-494 CDK6/CYCD1
miR-17 miR-20a, miR-20b Ephrin B2, B4
miR-125b-1-3p S1PR
miR-155 CYR 6, VEGF-A
miR-21 PTEN, positive regulator of VEGF-A and HIF-1α
miR-210 EFNA3, HOXA9, HSD17

Trophoblast proliferation miR-16, miR-29b Inhibits trophoblast proliferation
miR-34a SERPINA3
miR-210 KCMF-1
miR-155 CYCD1
miR-378a-5p, miR-376c, miR-21 Promotes trophoblast proliferation by nodal signaling pathway
miR-17-92 cluster Differentiation of primary trophoblasts

Inflammation miR-146a Inflammatory pathway
miR-155 IL-17A pathway
miR-494 Macrophage proliferation by reducing PGE2 production
miR-181a TGFβ pathway
miR-152 HLA-G
miR-210 STAT6/IL-4 pathway