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. 2017 Sep 25;8:1163. doi: 10.3389/fimmu.2017.01163

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Copyright © 2017 Joshi, Binai, Marabita, Sui, Altman, Heck, Tegnér and Schmidt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tregs counter activation-induced phosphorylation in responder Tcons. 32 phosphopeptides (corresponding to 28 proteins) change significantly (increased: 2, decreased: 30) upon Treg-mediated suppression (P < 0.05 and changing ≥25% in Tsup:Tstim). (A) Changes are represented as log₂ of average ratios for the indicated comparisons. Peptides are arranged by increasing log₂ ratio in Tsup:Tstim. (B) The 32 phosphopeptides with respective phosphosites and corresponding sequences and gene names are presented as individual log₂ ratio in 3 donors upon suppression and stimulation. Heat map color scale represents log₂ fold change ratio values.