Figure 6.
Proposed model of activation- and suppression-induced changes in the Tcon phosphoproteome. The scheme depicts the general upregulation of phosphorylation (P) upon TCR stimulation, which is largely counteracted by Tregs. Treg-suppressed cells partially resemble the unstimulated state and also present some additional changes not occurring upon activation. Tregs inhibit DEF6 phosphorylation at T595 and S597 sites, which is proposed to occur upon TCR activation and to confer interaction with the IP3R and downstream NFAT signaling and cytokine expression. Lower right panel modified from Ref. (8).