Fig. 6.

HDX studies indicating structural rigidity changes in the hPXR LBD due to the presence of SJB7 and SPA70. Overlays of the differential HDX data onto the crystal structure of the hPXR LBD (PDB code 5X0R) for a SJB7, b SPA70 c SJB7 with the subsequent addition of SRC-1, and d SPA70 with the subsequent addition of NCoR. The structures are color-coded according to the color bar at the bottom of the figure. Regions that were not covered are represented in white. See Supplementary Fig. 8 for additional information on the color coding and score used