Table 2.
Genes associated with glutamate receptor signaling differentially expressed in basal-like and luminal-like subtypes of bladder cancer
| Gene | ANCOVA FDR q-value | Median FC (Basal/Luminal) |
|---|---|---|
| ASTL | 2.65E-10 | -2.07 |
| CACNA2D1 | 3.18E-11 | 2.06 |
| CALB2 | 3.75E-17 | 2.09 |
| CAMK2A | 9.86E-20 | 2.49 |
| CASP14 | 1.31E-08 | 2.43 |
| CASP5 | 1.18E-21 | 3.64 |
| CBLN4 | 6.88E-04 | 49.23 |
| CEACAM3 | 2.14E-14 | 2.21 |
| CHGA | 3.17E-04 | 2.17 |
| CR2 | 1.45E-04 | 2.16 |
| CRH | 1.58E-21 | -358.55 |
| CSF3 | 8.47E-12 | 2.05 |
| CYP1A1 | 1.77E-11 | -2.45 |
| DAB1 | 2.65E-21 | -6.50 |
| DLGAP2 | 7.75E-04 | 44.44 |
| DRD1 | 2.88E-09 | -2.04 |
| ERBB4 | 1.41E-15 | -2.86 |
| F2 | 4.45E-05 | -60.69 |
| FMN1 | 5.06E-22 | 2.17 |
| FOLR3 | 6.13E-13 | 76.61 |
| GABBR2 | 1.13E-18 | -2.46 |
| GABRP | 2.33E-13 | 2.15 |
| GAL | 4.87E-10 | 3.51 |
| GAP43 | 4.82E-11 | 2.07 |
| GDNF | 4.17E-07 | 36.14 |
| GJB1 | 3.40E-10 | -3.64 |
| GNRH2 | 3.69E-06 | -33.66 |
| GRIA2 | 2.17E-03 | 35.40 |
| GRM3 | 8.00E-19 | -2.50 |
| GRM5 | 2.36E-11 | 2.11 |
| GRP | 1.89E-07 | 3.67 |
| HBE1 | 6.12E-06 | 29.59 |
| HNF1B | 3.63E-27 | -3.18 |
| HRH3 | 1.07E-17 | -125.54 |
| HTR2A | 6.52E-07 | 3.13 |
| HTR3A | 1.35E-06 | 66.51 |
| IFNG | 3.37E-14 | 3.06 |
| IL13 | 1.23E-05 | 39.43 |
| IL5RA | 9.57E-03 | 39.70 |
| KCNA2 | 6.49E-05 | 30.02 |
| KCNJ6 | 2.39E-05 | 49.11 |
| KLK11 | 1.28E-06 | 2.03 |
| L1CAM | 3.48E-20 | 2.01 |
| LHX1 | 1.71E-12 | 106.28 |
| LPA | 1.10E-06 | -3.06 |
| MUC2 | 1.10E-13 | -3.12 |
| NR1H4 | 3.94E-12 | -5.06 |
| NR2E1 | 2.44E-06 | -2.03 |
| NRXN1 | 3.98E-04 | 2.25 |
| PENK | 9.12E-06 | 71.70 |
| PIK3C2G | 4.46E-06 | 66.02 |
| PRKCG | 5.03E-07 | 44.46 |
| PTPRN | 3.47E-17 | 2.37 |
| PVALB | 3.43E-14 | -2.77 |
| RETN | 4.66E-09 | 2.73 |
| RNASE3 | 2.02E-05 | 2.21 |
| SGK2 | 8.93E-29 | -2.43 |
| SHH | 1.47E-14 | -5.66 |
| SLC26A5 | 9.52E-12 | -88.02 |
| SLC5A1 | 2.43E-07 | 2.31 |
| SLC6A4 | 8.57E-21 | -2.50 |
| SLCO1B3 | 8.89E-16 | 188.44 |
| SST | 2.83E-03 | -28.11 |
| TAC1 | 4.19E-07 | -52.37 |
| TFF2 | 4.53E-12 | -4.13 |
| TH | 7.99E-15 | -2.31 |
| TPO | 7.51E-04 | 42.51 |
| TTR | 1.73E-15 | -187.68 |
| TUBA4B | 6.44E-04 | 36.59 |
| UGT1A1 | 1.56E-23 | -2.25 |