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. 2017 Sep 1;7(9):1913–1925.

Figure 4.

Figure 4

PPIs upregulates FOXO1 though HIF-1α in SGC-7901 gastric cancer cells. A. TCGA databases show mRNA of HIF-1α have positive correlation with AJCC metastasis pathologic in gastric cancer patients. B. TCGA database reveal the positive correlation of mRNA between FOXO1 and HIF-1α. C. Scrambled siRNA or HIF-1α siRNA effect on the expression of FOXO1 of SGC7901 cells for 24 h (n=3). D. Scrambled siRNA or HIF-1α siRNA effect on the mRNA expression of FOXO1 of SGC7901 cells for 24 h (n=3). E. COCl2 effect on the Mrna expression of FOXO1 of SGC7901 cells at indicated concentration for 24 h (n=3). F. COCl2 effect on the expression of HIF-1, FOXO1 and β-actin of SGC7901 cells at indicated concentration for 24 h (n=3). G. PPIs effect on the expression of HIF-1α and β-actin of SGC7901 cells at indicated concentration for 24 h (n=3). H. Scrambled siRNA or HIF-1α siRNA effect on the expression CD63 and HIF-1α in exosome of SGC7901 cells for 24 h (n=3). Asterisk indicates a significant difference determined by unpaired two-tailed t test (*** indicates P < 0.001; ** indicates P < 0.01; * indicates P < 0.05).