. 2017 Sep 1;7(9):1937–1947.

Table 2.

Results of association analyses at 20q13.33 (RTEL1) before and after conditioning on rs6010620 or rs4809324

SNP	Position	SNP Type	Minor/Major Allele	MAF		Unadjusted		Conditional analysis

								Conditioned on rs6010620		D’	r²	Association Pattern

				Cases	Controls	P	OR (95% CI)	Conditional P	P for rs6010620
rs3827022	62195220	Missense	G/A	0.420	0.412	0.647	1.03 (0.91-1.17)	0.300	4.87E-07	0.36	0.08
rs114497943	62195426	Missense	G/C	0.0054	0.0005	4.33E-03	10.89 (1.39-85.15)	0.013	1.86E-07	NA	NA	↓pair
rs115211910	62195617	Missense	A/G	0.0016	0.0010	0.586	1.64 (0.27-9.80)	0.588	5.24E-07	NA	NA
rs3810487	62196033	Missense	G/A	0.465	0.475	0.531	0.96 (0.85-1.09)	0.031	5.46E-08	0.38	0.07
rs117986816	62196096	Missense	A/G	0.011	0.012	0.958	0.98 (0.54-1.78)	0.469	3.09E-07	0.74	0.02
rs310631	62196253	Missense	A/C	0.143	0.148	0.616	0.95 (0.80-1.14)	0.892	1.24E-06	0.27	0.01
rs201951872	62196600	Missense	C/A	0.0011	0.0036	0.114	0.3 (0.06-1.46)	0.200	1.29E-06	1.00	0.00
rs310632	62196807	Missense	A/G	0.0005	0.0005	0.951	1.09 (0.07-17.46)	0.971	5.80E-07	0.00
rs200473388	62200017	Missense	A/G	0.0044	0.0104	0.030	0.42 (0.18-0.94)	0.012	4.40E-07	0.86	0.01	↑pair
rs6090457	62200576	Missense	G/A	0.442	0.448	0.690	0.97 (0.86-1.11)	0.052	1.19E-07	0.38	0.08
rs2039369	62253821	Intron	G/A	0.417	0.416	0.980	1.00 (0.88-1.14)	0.803	6.02E-07	0.07	0.00
rs3848668	62293272	Missense	G/A	0.0027	0.0005	0.081	5.47 (0.64-46.89)	0.202	1.12E-06	NA	NA
rs199685200	62294237	Missense	G/A	0.0016	0.0005	0.276	3.28 (0.34-31.56)	0.359	7.10E-07	NA	NA
rs6010620^a	62309839	Intron	G/A	0.340	0.265	3.40E-07	1.43 (1.25-1.64)	NA	NA
rs4809324^b	62318220	Intron	G/A	0.140	0.107	2.02E-03	1.35 (1.12-1.64)	0.765	7.18E-05	0.96	0.30
rs141717966	62324183	Missense	A/G	0.0016	0.0035	0.259	0.47 (0.12-1.81)	0.143	3.68E-07	1.00	0.01
rs3208008	62326110	Missense	C/A	0.406	0.334	3.75E-06	1.36 (1.20-1.55)	0.232	0.026	0.90	0.59
rs115303435	62326159	Missense	A/G	0.047	0.028	2.03E-03	1.71 (1.21-2.42)	0.059	1.25E-05	0.85	0.07
rs137950052	62329672	Missense	A/G	0.0005	0.0005	0.951	1.09 (0.07-17.46)	0.832	4.57E-07	NA	NA
rs2315008	62343956	Intron	C/A	0.426	0.340	3.79E-08	1.44 (1.27-1.64)	9.12E-03	0.161	0.89	0.55
rs4809330	62349586	Intron	G/A	0.425	0.340	4.77E-08	1.44 (1.26-1.64)	0.011	0.139	0.89	0.55
rs199550529	62364653	Missense	A/C	0.0044	0.0119	0.011	0.37 (0.17-0.83)	4.12E-03	8.17E-07	0.94	0.02	↑pair
rs200051356	62366916	Missense	A/G	0.0005	0.0005	0.950	1.09 (0.07-17.47)	0.833	6.08E-07	NA	NA
rs116980580	62372798	Synonymous	A/G	0.0016	0.0040	0.172	0.41 (0.11-1.54)	0.104	3.66E-07	1.00	0.01
rs8957	62373707	Missense	A/C	0.436	0.352	9.58E-08	1.43 (1.25-1.63)	0.011	0.032	0.83	0.46	↓pair
rs932826	62380516	Intron	A/C	0.322	0.279	3.78E-03	1.23 (1.07-1.41)	0.177	1.24E-05	0.31	0.10
rs2281929	62422080	Missense	G/A	0.407	0.446	0.013	0.85 (0.75-0.9)	0.356	8.43E-06	0.54	0.09
rs2281534	62492922	Missense	T/A	0.131	0.134	0.784	0.97 (0.81-1.17)	0.287	3.30E-07	0.26	0.02

SNP reported by published GWAS;

NA, MAF too small to calculate accurate D’ or r2; 3, down arrow indicates a SNP pair for which significance decreases after conditioning on the other SNP.