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Case with heterogeneity of KRAS mutation comparing primary and metastatic lesions of a CRC patient (case B). Morphological characteristics of the primary lesion with wild-type KRAS showing areas of papillary (A) and cribiform architecture (B), with dystrophic calcification, necrosis, and squamous component (C). Same aspects as observed in lymph node metastasis with wild-type KRAS (D and E) and liver metastasis with KRAS c.35G>C (F).
