Silencing Rab14 suppresses the proliferation and migration of OSCC cell lines. Silencing Rab14 could induce significant repression of proliferation in (A) SCC4 and (B) Tca8113 cell lines using CCK-8 proliferation assays (Mean ± SEM, **, P<0.01, ***, P<0.001, t test). Transwell migration assays suggested that silencing Rab14 significantly induced inhibition of migration in (C) SCC4 and (D) Tca8113 cell lines (Mean ± SEM, ***, P<0.001, t test). (E) Western Blot showed knockdown of Rab14 downregulated the protein levels of Cyclin D1 and CXCR4 in SCC4 cells and Tca8113 cells. (F) Quantitative real-time PCR revealed that Rab14 silencing could significantly decrease the mRNA level of Cyclin D1 and CXCR4 in SCC4 cells and Tca8113 cells (Mean ± SEM, ***, P<0.001, t test).